Toxicological risk assessment for products

PUBLIC

  • Project managers, engineers, senior technicians, technicians in the food, pharmaceutical, cosmetic and packaging industries. 
  • Depending on how the public is made up, the training can be concentrated more scientifically on a particular aspect of the evaluation of the toxicological risk. 

AIMS

  • To understand the various aspects of the problem of toxicological safety of products. 
  • To have a technical and regulatory referential that provides an understanding of the methodological choices in the approach. 
  • To be able to understand the development and conclusions of a toxicological study report on the product. 

PROGRAMME

Origin and definitions 

General toxicological 

  • Origin of toxins and action sites 
  • Topical action mechanisms 
  • Systemic action mechanisms 
  • Main categories of toxic effects 

Toxicokinetics 

  • Dose-effect relation and bioavailability 
  • Variation factors 
  • Toxic parameters linked to the agent 
  • Toxic parameters linked to conditions of use 
  • Ways of metabolising toxins 

Biological risk 

  • Risk linked to live germs 
  • Risk linked to endotoxins and exotoxins 

Chemical risk 

  • Toxicological data files 
  • Exposure evaluation parameters 
  • Behaviour of toxins within the environment 
  • Toxicological reference values 

Radiotoxicity 

Genotoxicity and foetotoxicity 

Ecotoxicity 

Biocompatibility and interactions between container and content 

Method of evaluating toxicological risk 

  • Regulatory sources and specialist commissions 
  • Regulatory context specific to products 
  • Risk analysis 
  • Regulatory referential for toxicity evaluation methods 
  • Limits of methods and new approaches 

DURATION
2 days

TIMES
9:00 – 17:30

COST PER TRAINEE
1600 €

TEACHING RESOURCES 

  • The training combines theoretical explanations and practical discussions 
  • Expositions are based on the experiences of those involved 
  • A document listing all the training supports is provided 

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